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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players
PeerJ (San Francisco, CA), Vol.12, pp.1-23
16/12/2024
PMID: 39703911
Appears in Recent Faculty of Health Publications
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Source: InCites
Abstract
Background: Inhalation of hydrogen gas (H2 ) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A randomized, placebo-controlled, double-blind, crossover trial was conducted with professional male rugby players for 3 weeks. Participants underwent 1 week of H2 supplementation and 1 week of placebo treatment prior to daily sessions of high-intensity exercise training, separated by 1 week of low-intensity training as a washout.
Results: Two-way (supplementation and time) repeated-measures analyses of variance showed that NO, L-arginine, and tetrahydrobiopterin levels in the H2 inhalation group were significantly higher than those in the placebo group after exercise (D6) and remained higher after 24 h of rest (D7). Levels of hydroxydeoxyguanosine and interleukin 6 were lower in the H2 inhalation week than in the placebo week on D6 and D7. In addition, total antioxidant levels were significantly higher with H2 inhalation than with placebo.
Significance: These results suggest that H2 inhalation helps to maintain NO signaling after exercise and to alleviate inflammation and oxidative stress induced by high-intensity exercise training in professional athletes.
Details
- Title
- Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players
- Creators
- Yuqi Zhao - Nanjing Sport InstituteChaoqun Li - Shanghai University of SportShi Zhou - Southern Cross UniversityZhiguang Xu - Tianjin University of SportXin Huang - Tianjin University of SportLi Wen - Nanjing Sport Institute
- Publication Details
- PeerJ (San Francisco, CA), Vol.12, pp.1-23
- Publisher
- PeerJ Ltd.
- Grant note
- This work was supported by the National Natural Science Foundation of China (grant number 31271275).
- Identifiers
- 991013252861202368
- Copyright
- © 2024 Zhao et al.
- Academic Unit
- Human Sciences; Faculty of Health
- Language
- English
- Resource Type
- Journal article