Journal article
Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro
European journal of pharmaceutics and biopharmaceutics, Vol.69(1), pp.214-222
05/2008
PMID: 17983738
Metrics
7 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
The safety of topical application of Australian tea tree Oil (TTO) is confounded by a lack of transdermal penetration data, which adequately informs opinions and recommendations. In this study we applied TTO in its pure form and as a 20% solution in ethanol in vitro to human epidermal membranes from three different donors, mounted in horizontal Franz-type diffusion cells, using normal ‘in use’ dosing conditions (10 mg/cm2). In addition, we examined the effect of partially occluding the application site on the penetration of TTO components. Our data showed that only a small quantity of TTO components, 1.1–1.9% and 2–4% of the applied amount following application of a 20% TTO solution and pure TTO, respectively, penetrated into or through human epidermis. The largest TTO component penetrating the skin was terpinen-4-ol. Following partial occlusion of the application site, the penetration of terpinen-4-ol increased to approximately 7% of the applied TTO. Measurement of the rate of evaporation of tea tree oil from filter paper (7.4 mg/cm2) showed that 98% of the oil evaporated in 4 hours. Overall, it is apparent that the penetration of TTO components through human skin is limited.
Details
- Title
- Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro
- Creators
- Sheree E. Cross - University of QueenslandMichael Russell - New South Wales Department of Primary IndustriesIan Southwell - New South Wales Department of Primary Industries (Coffs Harbour)Michael S. Roberts - University of Queensland
- Publication Details
- European journal of pharmaceutics and biopharmaceutics, Vol.69(1), pp.214-222
- Publisher
- Elsevier B.V
- Identifiers
- 991013087512702368
- Copyright
- (c) 2007 Elsevier B.V. All rights reserved.
- Academic Unit
- Faculty of Science and Engineering
- Language
- English
- Resource Type
- Journal article