Files and links (2)
Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Glutamine metabolism and optimal immune and CNS function
Proceedings of the Nutrition Society, Vol.82(1), pp.22-31
02/2023
PMID: 36285520
Metrics
135 File views/ downloads
31 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
Nutrients can impact and regulate cellular metabolism and cell function which is particularly important for the activation and function of diverse immune subsets. Among the critical nutrients for immune cell function and fate, glutamine is possibly the most widely recognised immunonutrient, playing key roles in TCA cycle, heat shock protein responses and antioxidant systems. In addition, glutamine is also involved with inter-organ ammonia transport, and this is particularly important for not only immune cells, but also to the brain, especially in catabolic situations such as critical care and extenuating exercise. The well characterised fall in blood glutamine availability has been the main reason for studies to investigate the possible effects of glutamine replacement via supplementation but many of the results are in poor agreement. At the same time, a range of complex pathways involved in glutamine metabolism have been revealed via supplementation studies. This article will briefly review the function of glutamine in the immune system, with emphasis on metabolic mechanisms, and the emerging role of glutamine in the brain glutamate/gamma-amino buty-ric acid cycle. In addition, relevant aspects of glutamine supplementation are discussed.
Details
- Title
- Glutamine metabolism and optimal immune and CNS function
- Creators
- Philip Newsholme - Curtin UniversityGarron Thomas Dodd - The University of MelbourneVinicius Leonardo Sousa Diniz - Curtin UniversityVinicius Cruzat - Torrens University Australia
- Publication Details
- Proceedings of the Nutrition Society, Vol.82(1), pp.22-31
- Publisher
- Cambridge University Press
- Grant note
- This study was supported by Australian Research Council (ARC) Linkage grant LP190100130, National Health and Medical Research Council (NHMRC) of Australia (grants: 1160043, 2002427), Diabetes Australia Trust (grant: Y20G-DODG) and the Australian Research Council for research funding (grant: DP220102132) and the São Paulo Research Foundation (FAPESP), grant no. 2021/13119-2.
- Identifiers
- 991013071413702368
- Copyright
- Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article