Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study

Ysabel Jacob; Ryan S. Anderton; Jodie L. Cochrane Wilkie; Brent Rogalski; Simon M. Laws; Anthony Jones; Tania Spiteri; Dana Hince; Nicolas H. Hart

doi:10.1186/s40798-022-00522-y

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Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study

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Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study

Ysabel Jacob, Ryan S. Anderton, Jodie L. Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri, Dana Hince and Nicolas H. Hart

Sports medicine - open, Vol.8, 126

11/10/2022

DOI: https://doi.org/10.1186/s40798-022-00522-y

PMID: 36219268

Appears in Recent Faculty of Health Publications

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Abstract

Bone

Contact

Genes

Genetics

Injury

Ligament

Muscle

Non-contact

Original

Tendon

Introduction Australian Football is a dynamic team sport that requires many athletic traits to succeed. Due to this combination of traits, as well as technical skill and physicality, there are many types of injuries that could occur. Injuries are not only a hindrance to the individual player, but to the team as a whole. Many strength and conditioning personnel strive to minimise injuries to players to accomplish team success. Purpose To investigate whether selected polymorphisms have an association with injury occurrence in elite male Australian Football players. Methods Using DNA obtained from 46 elite male players, we investigated the associations of injury-related polymorphisms across multiple genes (ACTN3, CCL2, COL1A1, COL5A1, COL12A1, EMILIN1, IGF2, NOGGIN, SMAD6) with injury incidence, severity, type (contact and non-contact), and tissue (muscle, bone, tendon, ligament) over 7 years in one Australian Football League team. Results A significant association was observed between the rs1372857 variant in NOGGIN (p = 0.023) and the number of total muscle injuries, with carriers of the GG genotype having a higher estimated number of injuries, and moderate, or combined moderate and high severity rated total muscle injuries. The COL5A1 rs12722TT genotype also had a significant association (p = 0.028) with the number of total muscle injuries. The COL5A1 variant also had a significant association with contact bone injuries (p = 0.030), with a significant association being found with moderate rated injuries. The IGF2 rs3213221-CC variant was significantly associated with a higher estimated number of contact tendon injuries per game (p = 0.028), while a higher estimated number of total ligament (p = 0.019) and non-contact ligament (p = 0.002) injuries per game were significantly associated with carriage of the COL1A1 rs1800012-TT genotype. Conclusions Our preliminary study is the first to examine associations between genetic variants and injury in Australian Football. NOGGIN rs1372857-GG, COL5A1 rs12722-TT, IGF2 rs3213221-CC, and COL1A1 rs1800012-TT genotypes held various associations with muscle-, bone-, tendon- and ligament-related injuries of differing severities. To further increase our understanding of these, and other, genetic variant associations with injury, competition-wide AFL studies that use more players and a larger array of gene candidates is essential.

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Title: Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study
Creators: Ysabel Jacob - Edith Cowan University
Ryan S. Anderton - The University of Notre Dame Australia
Jodie L. Cochrane Wilkie - Edith Cowan University
Brent Rogalski - West Coast Eagles Football Club, Perth, WA Australia
Simon M. Laws - Edith Cowan University
Anthony Jones - West Coast Eagles Football Club, Perth, WA Australia
Tania Spiteri - Edith Cowan University
Dana Hince - The University of Notre Dame Australia
Nicolas H. Hart - Edith Cowan University
Publication Details: Sports medicine - open, Vol.8, 126
Publisher: Springer International Publishing
Identifiers: 991013087510602368
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study

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