Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

András Maifeld; Hendrik Bartolomaeus; Ulrike Löber; Ellen G Avery; Nico Steckhan; Lajos Markó; Nicola Wilck; Ibrahim Hamad; Urša Šušnjar; Anja Mähler; Christoph Hohmann; Chia-Yu Chen; Holger Cramer; Gustav Dobos; Till Robin Lesker; Till Strowig; Ralf Dechend; Danilo Bzdok; Markus Kleinewietfeld; Dominik N Müller; Andreas Michalsen; Sofia K Forslund

doi:10.1038/s41467-021-22097-0

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Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

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Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

András Maifeld, Hendrik Bartolomaeus, Ulrike Löber, Ellen G Avery, Nico Steckhan, Lajos Markó, Nicola Wilck, Ibrahim Hamad, Urša Šušnjar, Anja Mähler, …

Nature communications, Vol.12, pp.1-20

30/03/2021

DOI: https://doi.org/10.1038/s41467-021-22097-0

PMID: 33785752

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Abstract

Cardiovascular diseases

Dyslipidaemias

Hypertension

Metabolic disorders

Predictive markers

Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. Machine learning analysis of baseline immunome or microbiome data predicts sustained systolic blood pressure response within the fasting group, identifying CD8+ effector T cells, Th17 cells and regulatory T cells or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model. Here we report that the high-resolution multi-omics data highlight fasting as a promising non-pharmacological intervention for the treatment of high blood pressure in metabolic syndrome patients.

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Title: Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
Creators: András Maifeld - Max Delbrück Center for Molecular Medicine
Hendrik Bartolomaeus - Max Delbrück Center for Molecular Medicine
Ulrike Löber - Max Delbrück Center for Molecular Medicine
Ellen G Avery - Max Delbrück Center for Molecular Medicine
Nico Steckhan - Humboldt-Universität zu Berlin
Lajos Markó - Humboldt-Universität zu Berlin
Nicola Wilck - Max Delbrück Center for Molecular Medicine
Ibrahim Hamad - VIB-UGent Center for Inflammation Research
Urša Šušnjar - Max Delbrück Center for Molecular Medicine
Anja Mähler - Humboldt-Universität zu Berlin
Christoph Hohmann - Immanuel Krankenhaus
Chia-Yu Chen - Max Delbrück Center for Molecular Medicine
Holger Cramer - University of Duisburg-Essen
Gustav Dobos - University of Duisburg-Essen
Till Robin Lesker - Helmholtz Centre for Infection Research
Till Strowig - Medizinische Hochschule Hannover
Ralf Dechend - Max Delbrück Center for Molecular Medicine
Danilo Bzdok - Montreal Neurological Institute and Hospital
Markus Kleinewietfeld - VIB-UGent Center for Inflammation Research
Dominik N Müller - Max Delbrück Center for Molecular Medicine
Andreas Michalsen - Humboldt-Universität zu Berlin
Sofia K Forslund - Max Delbrück Center for Molecular Medicine
Publication Details: Nature communications, Vol.12, pp.1-20
Publisher: Nature Publishing Group
Identifiers: 991013035749102368
Copyright: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients

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