Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Omar Mohammed Amen; Satyajit D. Sarker; Reena Ghildyal; Aditya Arya

doi:10.3389/fphar.2019.00977

Back

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Journal article

Open access

Peer reviewed

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Omar Mohammed Amen, Satyajit D. Sarker, Reena Ghildyal and Aditya Arya

Frontiers in pharmacology, Vol.10, pp.1-21

10/09/2019

DOI: https://doi.org/10.3389/fphar.2019.00977

PMCID: PMC6747043

PMID: 31551782

Files and links (2)

pdf

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach3.74 MBDownload View

Published (Version of record)CC BY V4.0, Open Access

url

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular ApproachView

Published (Version of record)CC BY V4.0, Open

Metrics

1 File views/ downloads

1 Record Views

115 Times Cited - Web of Science

See more details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Abstract

cardiac dysfunction

endoplasmic reticulum stress

inflammation

insulin resistance

obesity

oxidative stress

Pharmacology

unfolded protein response

Obesity has been implicated as a risk factor for insulin resistance and cardiovascular diseases (CVDs). Although the association between obesity and CVD is a well-established phenomenon, the precise mechanisms remain incompletely understood. This has led to a relative paucity of therapeutic measures for the prevention and treatment of CVD and associated metabolic disorders. Recent studies have shed light on the pivotal role of prolonged endoplasmic reticulum stress (ERS)-initiated activation of the unfolded protein response (UPR), the ensuing chronic low-grade inflammation, and altered insulin signaling in promoting obesity-compromised cardiovascular system (CVS). In this aspect, potential ways of attenuating ERS-initiated UPR signaling seem a promising avenue for therapeutic interventions. We review intersecting role of obesity-induced ERS, chronic inflammation, insulin resistance, and oxidative stress in the discovery of targeted therapy. Moreover, this review highlights the current progress and strategies on therapeutics being explored in preclinical and clinical research to modulate ERS and UPR signalling.

Details

Title: Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach
Creators: Omar Mohammed Amen - Taylors University
Satyajit D. Sarker - Liverpool John Moores University
Reena Ghildyal - University of Canberra
Aditya Arya - University of Melbourne
Publication Details: Frontiers in pharmacology, Vol.10, pp.1-21
Publisher: Frontiers Media S.A
Grant note: This review is supported by Taylor’s Research Grant—Major Funding Scheme (TRGS-MFS) Project No. TRGS/MFS/2/2016/SOM/003.
Identifiers: 991013036341102368
Copyright: Copyright © 2019 Amen, Sarker, Ghildyal and Arya. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

Files and links (2)

Metrics

UN Sustainable Development Goals (SDGs)

Abstract

Details

Southern Cross University Social media