Journal article
Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials
International Journal of Obesity, Vol.45(8), pp.1631-1643
08/2021
PMID: 33976376
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Source: InCites
Abstract
Background/objectives: A systematic review with meta-analysis was conducted to synthesise evidence on the efficacy of dietary supplements containing isolated organic compounds for weight loss.
Subjects/methods: Four electronic databases (Medline, Embase, Web of Science, Cinahl) were searched until December 2019. Sixty-seven randomised placebo-controlled trials of dietary supplements containing isolated organic compounds for weight loss were included. Meta-analyses were conducted for chitosan, glucomannan, conjugated linoleic acid and fructans, comparing mean weight difference post-intervention between participants receiving the dietary supplement or placebo.
Results: Statistically significant weight differences compared to placebo were observed for chitosan (-1.84 kg; 95% confidence interval [CI] -2.79, -0.88; p < 0.01), glucomannan (-1.27 kg; 95%CI -2.45, -0.09; p = 0.04), and conjugated linoleic acid (-1.08 kg; 95%CI -1.61, -0.55; p < 0.01). None met our threshold for clinical significance (≥2.5 kg). There was no statistically significant effect on weight for fructans compared to placebo (p = 0.24). For dietary supplements with an inadequate number of trials for meta-analysis, a statistically and borderline clinically significant weight difference compared to placebo was found for modified cellulose, manno-oligosaccharides (in males), blood orange juice extract, and three multiple-ingredient dietary supplements. These were only reported in one trial of each. Thus, more evidence is needed before recommending them for weight loss.
Conclusions: While some dietary supplements containing isolated organic compounds warrant further investigation to determine efficacy and safety, there is currently insufficient evidence to recommend any of these dietary supplements for weight loss.
Details
- Title
- Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials
- Creators
- Erica Bessell - University of SydneyAlison Maunder - University of SydneyRomy Lauche - Southern Cross UniversityJon Adams - University of Technology SydneyAmanda Sainsbury - University of Western AustraliaNicholas R Fuller - University of Sydney
- Publication Details
- International Journal of Obesity, Vol.45(8), pp.1631-1643
- Publisher
- Nature Publishing Group
- Grant note
- This work was supported by an Australian Government Research Training Programme (RTP) Scholarship awarded to EB, and by an NHMRC Senior Research Fellowship to AS.
- Identifiers
- 991012948490902368
- Copyright
- © The Author(s), under exclusive licence to Springer Nature Limited 2021.
- Academic Unit
- School of Health and Human Sciences; National Centre for Naturopathic Medicine; Faculty of Health
- Language
- English
- Resource Type
- Journal article