Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: a single-blind, add-on therapy, randomized controlled clinical trial

A. Tavakoli; H. Molavi Vardanjani; F. Namjouyan; H. Cramer; M. Pasalar

doi:10.26355/eurrev_202202_28013

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Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: a single-blind, add-on therapy, randomized controlled clinical trial

Journal article

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Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: a single-blind, add-on therapy, randomized controlled clinical trial

A. Tavakoli, H. Molavi Vardanjani, F. Namjouyan, H. Cramer and M. Pasalar

European review for medical and pharmacological sciences, Vol.26(3), pp.1033-1041

2022

DOI: https://doi.org/10.26355/eurrev_202202_28013

PMID: 35179770

Appears in Recent National Centre for Naturopathic Medicine Publications

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Abstract

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

COVID-19

SARS-CoV-2

Hospital stay

Barely

Persian medicine

Iran

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is a debilitating disease with numerous medical and non-medical consequences. Our study aimed to evaluate the efficacy of Persian barley water in controlling the clinical outcomes of hospitalized COVID-19 patients. PATIENTS AND METHODS: This was a single-blind, add-on therapy, randomized controlled clinical trial conducted in Shiraz, Iran, from January to March 2021. One hundred hospitalized COVID-19 patients with moderate disease severity were randomly allocated to receive routine treatment (per local protocols) with or without 250 ml of Persian barley water (PBW) daily for two weeks. Clinical outcomes and blood tests were recorded before and after the study period. Multivariable modeling was applied using Stata software for data analysis. RESULTS: The PBW product passed our standardization and safety assessments. Length of hospital stay (LHS) was 4.5 days shorter in the intervention group than the control group regardless of history of cigarette smoking (95% confidence interval: -7.22, -1.79 days). Also, body temperature, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and creatinine significantly dropped in the intervention group compared to the control group. No adverse events related to PBW occurred. CONCLUSIONS: This clinical trial demonstrated the efficacy of PBW in minimizing the LHS, fever, and levels of ESR, CRP, and creatinine among hospitalized COVID-19 patients with moderate disease severity. More robust trials can help find safe and effective herbal formulations as treatments for COVID-19.

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Title: Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: a single-blind, add-on therapy, randomized controlled clinical trial
Creators: A. Tavakoli - Shiraz University of Medical Sciences
H. Molavi Vardanjani - Shiraz University
F. Namjouyan - Shiraz University
H. Cramer - Univ Duisburg Essen, Dept Internal & Integrat Med, Essen, Germany
M. Pasalar - Shiraz University
Publication Details: European review for medical and pharmacological sciences, Vol.26(3), pp.1033-1041
Publisher: Verduci Publisher
Number of pages: 9
Identifiers: 991013035761702368
Copyright: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: a single-blind, add-on therapy, randomized controlled clinical trial

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