Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis

Yan Luo; Masoud Rahmati; Abdolreza Kazemi; Wenbing Liu; Seung Won Lee; Razak M. Gyasi; Guillermo F. López Sánchez; Ai Koyanagi; Lee Smith; Dong Keon Yon

doi:10.1016/j.heliyon.2024.e30874

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Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis

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Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis

Yan Luo, Masoud Rahmati, Abdolreza Kazemi, Wenbing Liu, Seung Won Lee, Razak M. Gyasi, Guillermo F. López Sánchez, Ai Koyanagi, Lee Smith and Dong Keon Yon

Heliyon, Vol.10(10), e30874

30/05/2024

DOI: https://doi.org/10.1016/j.heliyon.2024.e30874

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Abstract

Knee osteoarthritis

Meta-analysis

Physical therapy

Systematic review

Ultrasonic therapy

Background Therapeutic ultrasound (US) is a treatment for knee osteoarthritis (KOA), but its efficacy and safety are unclear. The objective of this study is to quantify the effect of US on pain relief and function recovery in KOA, and to analyze the US treatment duration and parameters on treatment outcome. Methods We searched PubMed, MEDLINE, EMBASE, Google Scholar, Cochrane databases and ClinicalTrials.gov databases up to April 7, 2023. RCTs that compared the efficacy of therapeutic US with the control in KOA were included in the study, and the methodological quality of the trials was assessed using the Cochrane Risk of Bias tool. Results Twenty-one RCTs (1315 patients) were included. US had a positive effect on visual analog scale (VAS) (SMD = −0.64, 95 % CI [-0.88, −0.40], I2 = 71 %) and Western Ontario and McMaster Universities (WOMAC) total scale (SMD = −0.45, 95 % CI [-0.69, −0.20]; I2 = 67 %). Pulsed US with an intensity ≤2.5 W/cm2 reduced visual analog scale (VAS), and differed in sessions (24 sessions (SMD = −0.80, 95 % CI [-1.07, −0.53], I2 = 0 %) vs 10 sessions (SMD = −0.71, 95 % CI [-1.09, −0.33], I2 = 68 %)). For pulsed US, a duration of treatment of 4–8 weeks (SMD = −0.69, 95 % CI [-1.13, −0.25], I2 = 73 %) appeared to be superior to ≤4 weeks (SMD = −0.77, 95 % CI [-1.04, −0.49], I2 = 0 %) for reducing visual analog scale (VAS). No US treatment-related adverse events were reported. Conclusion Therapeutic US may be a safe and effective treatment for patients with KOA. The mode, intensity, frequency, and duration of US may affect the effectiveness of pain relief. Pulsed US with an intensity ≤2.5 W/cm2, 24 sessions, and a treatment duration of ≤4 weeks appears to have better pain relief.

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Title: Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis
Creators: Yan Luo - Xiangya Hospital Central South University
Masoud Rahmati - Aix-Marseille University
Abdolreza Kazemi - Vali-E-Asr University of Rafsanjan (Rafsanjan, Iran)
Wenbing Liu - Wenzhou Medical University
Seung Won Lee - Sungkyunkwan University
Razak M. Gyasi - Southern Cross University
Guillermo F. López Sánchez - University of Murcia (Murcia, Spain)
Ai Koyanagi - Parc Sanitari Sant Joan de Déu
Lee Smith - Anglia Ruskin University
Dong Keon Yon - Kyung Hee University Medical Center
Publication Details: Heliyon, Vol.10(10), e30874
Publisher: Elsevier Ltd
Identifiers: 991013192112602368
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis

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