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Effects of alternate-day fasting and time-restricted feeding in obese middle-aged female rats4.03 MB
Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Effects of alternate day fasting and time-restricted feeding in obese middle-aged female rats
Nutrition (Burbank, Los Angeles County, Calif.), Vol.116, 112198
12/2023
PMID: 37717500
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Abstract
Objectives
Obesity is a multifactorial condition associated with metabolic alterations that can be aggravated during female aging. Calorie restriction via intermittent fasting (IF) diets may reduce body weight and therefore have the potential to decrease obesity and associated comorbidities, such as insulin resistance. This study investigated the effects of two IF protocols, alternate-day fasting (ADF) and time-restricted feeding (TRF) in middle-aged obese female rats.
Methods
Wistar rats (age 15 mo) were fed with standard chow or high-fat diet for 8 wk and then separated into the following groups (n = 5–8 each) for another 8 wk: control (received standard chow), obese (received high-fat diet), obese + ADF (24-h fasting protocol), and obese + TRF (14 h daily).
Results
At the end of the study, both IF protocols were able to reduce body weight and body mass index compared with the obese group. However, no changes were observed in adiposity and glucose homeostasis. We also found an increase in total leukocytes, lymphocytes, and monocytes in the TRF group and a higher number of platelets in the ADF group. Blood lipid profiles, including triglycerides and high-density lipoprotein, as well as liver stress responses, such as heat shock protein 70 and malondialdehyde, were not changed by IF.
Conclusions
Although ADF and TRF protocols resulted in a reduction of body weight and body mass index, these dietary interventions did not promote health benefits, such as reducing blood lipid profile, adiposity, and insulin resistance. In addition, ADF and TRF increased inflammatory biomarkers, which may increase the risk of obesity-associated comorbidities.
Details
- Title
- Effects of alternate day fasting and time-restricted feeding in obese middle-aged female rats
- Creators
- Bruna L. Endl Bilibio (Author) - Regional University of Northwestern Rio Grande do Sul StateWelerson R. dos Reis (Author) - Regional University of Northwestern Rio Grande do Sul StateLetícia Compagnon (Author) - Regional University of Northwestern Rio Grande do Sul StateDiovana G. de Batista (Author) - Regional University of Northwestern Rio Grande do Sul StateLucas M. Sulzbacher (Author) - Regional University of Northwestern Rio Grande do Sul StateJuliana F. Pinheiro (Author) - Regional University of Northwestern Rio Grande do Sul StateMirna S. Ludwig (Author) - Regional University of Northwestern Rio Grande do Sul StateMatias N. Frizzo (Author) - Regional University of Northwestern Rio Grande do Sul StateVinicius Cruzat (Author) - Southern Cross UniversityThiago Gomes Heck (Author) - Regional University of Northwestern Rio Grande do Sul State
- Publication Details
- Nutrition (Burbank, Los Angeles County, Calif.), Vol.116, 112198
- Publisher
- Elsevier
- Identifiers
- 991013136813702368
- Copyright
- © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article