Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

Iberê  Machado Kostrycki; Guilherme  Wildner; Yohanna  Hannah  Donato; Analú  Bender dos Santos; Lílian Corrêa Costa Beber; Matias  Nunes Frizzo; Mirna  Stela Ludwig; Kevin Noel Keane; Vinicius Cruzat; Cláudia Ramos Rhoden; Thiago  Gomes Heck

doi:10.1155/2019/4858740

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Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

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Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

Iberê Machado Kostrycki, Guilherme Wildner, Yohanna Hannah Donato, Analú Bender dos Santos, Lílian Corrêa Costa Beber, Matias Nunes Frizzo, Mirna Stela Ludwig, Kevin Noel Keane, Vinicius Cruzat, Cláudia Ramos Rhoden, …

Journal of Diabetes Research, Vol.2019, pp.1-14

06/01/2019

DOI: https://doi.org/10.1155/2019/4858740

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Abstract

Obesity, air pollution, and exercise induce alterations in the heat shock response (HSR), in both intracellular 70 kDa heat shock proteins (iHSP70) and the plasmatic extracellular form (eHSP72). Extra-to-intracellular HSP70 ratio (H-index = eHSP70/iHSP70 ratio) represents a candidate biomarker of subclinical health status. This study investigated the effects of moderate- and high-intensity exercise in the HSR and oxidative stress parameters, in obese mice exposed to fine particulate matter (PM2.5). Thirty-day-old male isogenic B6129F2/J mice were maintained for 16 weeks on standard chow or high-fat diet (HFD). Then, mice were exposed to either saline or 50 μg of PM2.5 by intranasal instillation and subsequently maintained at rest or subjected to moderate- or high-intensity swimming exercise. HFD mice exhibited high adiposity and glucose intolerance at week 16th. HFD mice submitted to moderate- or high-intensity exercise were not able to complete the exercise session and showed lower levels of eHSP70 and H-index, when compared to controls. PM2.5 exposure modified the glycaemic response to exercise and modified hematological responses in HFD mice. Our study suggests that obesity is a critical health condition for exercise prescription under PM2.5 exposure.

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Title: Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter
Creators: Iberê Machado Kostrycki
Guilherme Wildner
Yohanna Hannah Donato
Analú Bender dos Santos
Lílian Corrêa Costa Beber
Matias Nunes Frizzo
Mirna Stela Ludwig
Kevin Noel Keane - Curtin University
Vinicius Cruzat - Torrens University Australia
Cláudia Ramos Rhoden
Thiago Gomes Heck
Publication Details: Journal of Diabetes Research, Vol.2019, pp.1-14
Publisher: Hindawi Limited
Identifiers: 991013071412902368
Copyright: © 2019 Iberê Machado Kostrycki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

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