Journal article
Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial
The journal of alternative and complementary medicine (New York, N.Y.), Vol.27(3), pp.255-262
16/03/2021
PMID: 33512251
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Source: InCites
Abstract
Introduction: Oral mucositis (OM) is the most prevalent side effect in patients with head and neck cancer (HNC). It causes an obvious decrease in quality of life (QoL) in these patients, so different medications have been recommended for OM, however, without optimal response. This randomized trial aimed to assess the effects of a honey–lemon spray compared with benzydamine hydrochloride in prevention of radiation-induced OM in patients with HNC.
Materials and Methods: Forty-six patients with HNC received external beam radiotherapy for 5 days per week. Patients were randomized to treatment with either benzydamine hydrochloride spray or honey–lemon spray for 5 weeks and continued for 1 week after the end of treatment. The oral cavity was examined weekly, with a score given to each site based on the degree of mucositis using a 4-point scale, and a mean mucositis score was calculated as the primary outcome. Occurrence of OM, pain, QoL, and adverse effects were defined as secondary outcomes. Patients, therapists, and outcome assessors were blinded to group allocation.
Results: No significant group differences occurred in the mucositis score, pain, or QoL. Mucositis occurrence rates were higher in the benzydamine hydrochloride group compared with the honey–lemon group (hazard ratio = 2.1, 95% confidence interval: 1.1 to 4.2). Two patients in the honey–lemon group had mild nausea and burning throat; no adverse effects occurred in the benzydamine hydrochloride group.
Conclusions: There were no significant group differences in mucositis severity between patients treated with honey–lemon spray and benzydamine hydrochloride. The potential preventive effects of honey–lemon spray need to be confirmed in further trials.
Details
- Title
- Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial
- Creators
- Ahmad Ameri - Imam Hossein HospitalSanaz Poshtmahi - Tarbiat Modares UniversityGhazaleh Heydarirad - Shahid Beheshti University of Medical SciencesHolger Cramer - Kliniken Essen-MitteRasoul Choopani - Shahid Beheshti University of Medical SciencesHoma Hajimehdipoor - Shahid Beheshti University of Medical SciencesSamira Azghandi - Shahid Beheshti University of Medical SciencesMehdi Pasalar - Shiraz University of Medical Sciences
- Publication Details
- The journal of alternative and complementary medicine (New York, N.Y.), Vol.27(3), pp.255-262
- Publisher
- Mary Ann Liebert, Inc., publishers
- Identifiers
- 991013035762202368
- Copyright
- Copyright 2021, Mary Ann Liebert, Inc., publishers.
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article