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Published (Version of record)CC BY V4.0, Open
Journal article
Effect of High Intensity Power Training on Cognitive Function in Older Adults with Type 2 Diabetes: Secondary Outcomes of the GREAT2DO Study
Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Vol.77(10), pp.1975-1985
10/2022
PMID: 35436329
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Source: InCites
Abstract
We sought to determine the effects of 12 months of power training on cognition, and whether improvements in body composition, muscle strength and/or aerobic capacity (VO2peak) were associated with improvements in cognition in older adults with type 2 diabetes (T2D). Participants with T2D were randomized to power training or low intensity sham exercise control condition, three days per week for 12 months. Cognitive outcomes included memory, attention/speed, executive function, and global cognition. Other relevant outcomes included VO2peak, strength, and whole body and regional body composition. One hundred and three adults with T2D (mean age 67.9 years; SD 5.9; 50.5% women) were enrolled and analyzed. Unexpectedly, there was a nearly significant improvement in global cognition (P=0.05) in the sham group relative to power training, although both groups improved over time (P<0.01). There were significant interactions between group allocation and body composition or muscle strength in the models predicting cognitive changes. Therefore, after stratifying by group allocation, improvements in immediate memory were associated with increases in relative skeletal muscle mass (r=0.38, P=0.03), reductions in relative body fat (r=-0.40, P=0.02), and increases in knee extension strength were directly related to changes in executive function (r=-0.41, P=0.02) within the power training group. None of these relationships were present in the sham group (P>0.05). Although power training did not significantly improve cognition compared to low-intensity exercise control, improvements in cognitive function in older adults were associated with hypothesized improvements in body composition and strength after power training.
Details
- Title
- Effect of High Intensity Power Training on Cognitive Function in Older Adults with Type 2 Diabetes: Secondary Outcomes of the GREAT2DO Study
- Creators
- Ren Ru Zhao - University of SydneyYorgi Mavros - University of SydneyJacinda Meiklejohn - University of SydneyKylie A Anderberg - University of SydneyNalin Singh - University of SydneyShelley Kay - University of SydneyMichael K Baker - Australian Catholic UniversityYi Wang - Baker Heart and Diabetes InstituteMike Climstein - Southern Cross UniversityAnthony O'Sullivan - University of New South WalesNathan De Vos - Balmain HospitalBernhard T Baune - University of MünsterSteven N Blair - University of South CarolinaDavid Simar - University of New South WalesMaria A Fiatarone Singh - University of Sydney
- Publication Details
- Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Vol.77(10), pp.1975-1985
- Publisher
- Oxford University Press
- Number of pages
- 11
- Grant note
- The GREAT2DO study was funded by project grant 512381 from the National Health and Medical Research Council and grants from the Australian Diabetes Society and Diabetes Australia. Yorgi Mavros was supported by the Australian Postgraduate Award Scholarship. Yi Wang was supported by University of Sydney International Postgraduate Research Scholarship.
- Identifiers
- 991013013792902368
- Copyright
- Published by Oxford University Press on behalf of The Gerontological Society of America 2022. Copyright © 2022 Oxford University Press
- Academic Unit
- School of Health and Human Sciences; Human Sciences; Faculty of Health
- Language
- English
- Resource Type
- Journal article