Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients

Shelly Wen; Lucy Manuel; Moira Doolan; Justin Westhuyzen; Thomas P. Shakespeare; Noel J. Aherne

doi:10.2147/BCTT.S236483

Back

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients

Journal article

Open access

Peer reviewed

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients

Shelly Wen, Lucy Manuel, Moira Doolan, Justin Westhuyzen, Thomas P. Shakespeare and Noel J. Aherne

Breast cancer targets and therapy, Vol.2020(12), pp.27-35

06/03/2020

DOI: https://doi.org/10.2147/BCTT.S236483

PMCID: PMC7064282

PMID: 32184654

Files and links (2)

pdf

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients492.64 kBDownload View

AcceptedCC BY-NC V3.0, Open Access

url

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer PatientsView

Published (Version of record)CC BY-NC V3.0, Open

Metrics

1 File views/ downloads

7 Record Views

15 Times Cited - Web of Science

See more details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Abstract

Life Sciences & Biomedicine

Oncology

Science & Technology

Dose fractionation

Mastectomy

Radiotherapy

Survival analysis

Triple negative breast neoplasms

Purpose: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatment-related factors. Patients and Methods: The electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Overall survival and DFS times were analyzed using the Kaplan-Meier method; multivariate Cox proportional hazard regression modelling was used to assess the significance of prognostic factors. Results: The majority of tumors were T1 (51.9%), followed by T2 (39.2%) and T3 (6.1%). For the whole group, mean DFS was 106.4 (SD 48.7) months; OS 109.4 (SD 52.1) months. Radiotherapy technique, fractionation protocol and laterality were not significant factors for DFS or OS (p> 0.05). However, compared to breast conservation, mastectomy was associated with poorer DFS (mean 114.2 vs 65.2 months; p< 0.0001) and poorer OS (mean 115.5 vs 80.5 months; p=0.0015). The mastectomy group had fewer patients with tumor size T1 (p=0.001) and higher proportions of T3 (p=0.001) and T4 (p=0.02). On multivariate analysis, tumor size T3/T4 and nodal status N2/N3 were significant factors for reduced DFS (p=0.023 and p=0.0003 respectively). Tumor size T3/T4 was the only significant prognostic factor for reduced OS (p=0.019). Conclusion: Advanced disease exhibited by tumor size > 5cm and positive nodal status is associated with poorer DFS in TNBC patients. Radiotherapy technique or fractionation protocol were not associated with differences in DFS or OS in our patient cohort.

Details

Title: Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients
Creators: Shelly Wen - Mid North Coast Cancer Institute, Coffs Harbour
Lucy Manuel - Mid North Coast Cancer Institute, Coffs Harbour
Moira Doolan - Mid North Coast Cancer Institute, Coffs Harbour
Justin Westhuyzen - Mid North Coast Cancer Institute, Coffs Harbour
Thomas P. Shakespeare - Mid North Coast Cancer Institute, Coffs Harbour
Noel J. Aherne - Mid North Coast Cancer Institute, Coffs Harbour
Publication Details: Breast cancer targets and therapy, Vol.2020(12), pp.27-35
Publisher: Dove Medical Press Ltd
Number of pages: 9
Identifiers: 991013098101302368
Copyright: © 2020 Wen et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/).
Academic Unit: Coffs Harbour Campus Administration
Language: English
Resource Type: Journal article

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients

Files and links (2)

Metrics

UN Sustainable Development Goals (SDGs)

Abstract

Details

Southern Cross University Social media