Journal article
Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective
Advances in parasitology, Vol.104, pp.247-326
2019
PMID: 31030770
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Source: InCites
Abstract
Soil-transmitted helminth (STH) infections represent a major public health problem globally, particularly among socio-economically disadvantaged populations. Detection of STH infections is often challenging, requiring a combination of diagnostic techniques to achieve acceptable sensitivity and specificity, particularly in low infection-intensity situations. The microscopy-based Kato-Katz remains the most widely used method but has low sensitivity in the detection of, for instance, Strongyloides spp. infections, among others. Antigen/antibody assays can be more sensitive but are parasite species-specific. Highly sensitive PCR methods have been developed to be multiplexed to allow multi-species detection. Novel diagnostic tests for all STH species are needed for effective monitoring, evaluation of chemotherapy programmes, and to assess the potential emergence of parasite resistance. This review discusses available diagnostic methods for the different stages of STH control programmes, which vary in sensitivity and spectrum of detection requirements, and tools to evaluate drug efficacy and resistance.
Details
- Title
- Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective
- Creators
- Polydor Ngoy Mutombo - Burnet InstituteNicola W Y Man - Aarhus UniversityPeter Nejsum - Aarhus UniversityRobert Ricketson - Emerging Pathogens InstituteCatherine A Gordon - QIMR Berghofer Medical Research InstituteGemma Robertson - Scientific ServicesArchie C A Clements - Curtin UniversityNathalie Chacón-Fonseca - Central University of VenezuelaVeeranoot Nissapatorn - Walailak UniversityJoanne P Webster - Royal Veterinary CollegeMary-Louise McLaws - UNSW Sydney
- Publication Details
- Advances in parasitology, Vol.104, pp.247-326
- Publisher
- Academic Press
- Identifiers
- 991013036330102368
- Copyright
- Copyright © 2019 Elsevier Ltd. All rights reserved.
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article