Journal article
Developmental outcomes following vaccine-proximate febrile seizures in children
Neurology, Vol.95(3), pp.E226-E238
01/07/2020
PMID: 32611632
Metrics
5 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
Objective To compare the developmental and behavioral outcomes of children experiencing an initial vaccine-proximate (VP) febrile seizure (FS) to those having a non–VP-FS (NVP-FS) and controls who have not had a seizure.
Methods In this prospective multicenter cohort study, children with their first FS before 30 months of age between May 2013 and April 2016 were recruited from 4 Australian pediatric hospitals and classified as having VP-FS or NVP-FS. Similar-aged children with no seizure history were recruited as controls. The Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) was administered to participants with FS 12 to 24 months after their initial FS and to controls 12 to 42 months of age at the time of assessment. The primary outcome was the Bayley-III cognitive score. Children's preacademic skills were assessed with the Woodcock-Johnson Tests of Achievement, Third Edition, and their behavior and executive functioning were obtained from parent questionnaires.
Results There was no significant difference in cognitive function between children with VP-FS (n = 62), those with NVP-FS (n = 70), and controls (n = 90) (F2,219 = 2.645, p = 0.07). There were no differences between the groups for all other measures and no increased risk of borderline/significant impairment or behavior in the clinical range in children with VP-FS compared to those with NVP-FS or controls.
Conclusion VP-FS was not associated with an increased risk of developmental or behavioral problems in young children compared to children with NVP-FS or controls. Parents and providers should be reassured by the absence of adverse effects of VP-FS on the development of children.
Details
- Title
- Developmental outcomes following vaccine-proximate febrile seizures in children
- Creators
- Lucy Deng - Children's Hospital at WestmeadNicholas Wood - Children's Hospital at WestmeadKristine Macartney - University of AdelaideMichael Gold - Royal Children's HospitalNigel Crawford - University of MelbourneJim Buttery - Monash UniversityPeter Richmond - Telethon Kids InstituteBelinda Barton - University of Western Australia
- Publication Details
- Neurology, Vol.95(3), pp.E226-E238
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 13
- Grant note
- 1049557 / Australian National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia APP1063629 / NHMRC Career Development Fellowship; National Health and Medical Research Council (NHMRC) of Australia University of Sydney Research Training Program scholarship
- Identifiers
- 991013093610302368
- Copyright
- © 2020 American Academy of Neurology.
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article