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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review
BMC Musculoskeletal Disorders, Vol.21(1), pp.1-12
20/03/2020
PMCID: PMC7083062
PMID: 32192466
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Source: InCites
Abstract
Background: The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia.
Methods: A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken.
Results: From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth.
Conclusion: The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.
Details
- Title
- Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review
- Creators
- Sharon Erdrich - Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia. Sharon.erdrich@sydney.edu.auJason A Hawrelak - College of Health and Medicine, University of Tasmania, Hobart, Tasmania, AustraliaStephen P Myers - NatMed Research Unit, Division of Research, Southern Cross University, Lismore, New South Wales, AustraliaJoanna E Harnett - Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
- Publication Details
- BMC Musculoskeletal Disorders, Vol.21(1), pp.1-12
- Publisher
- BioMed Central Ltd.; England
- Identifiers
- 991012925688802368
- Copyright
- © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Academic Unit
- National Centre for Naturopathic Medicine; Office of the Vice Chancellor; Office of Deputy Vice Chancellor, Research
- Language
- English
- Resource Type
- Journal article