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Journal article
Comprehensive Lifestyle-Modification in Patients with Ulcerative Colitis–A Randomized Controlled Trial
Journal of Clinical Medicine, Vol.9(10), 3087
24/10/2020
PMID: 32987894
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Source: InCites
Abstract
Patients with ulcerative colitis suffer from impaired health-related quality of life (HrQoL). Comprehensive lifestyle-modification might increase HrQoL and decrease disease activity. Ninety-seven patients in clinical remission with impaired HrQoL were randomly assigned to a 10 week comprehensive lifestyle-modification program (LSM; n = 47; 50.28 ± 11.90 years) or control (n = 50; 45.54 ± 12.49 years) that received a single workshop of intense training in naturopathic self-help strategies. Primary outcome was HrQoL (Inflammatory Bowel Disease Questionnaire; IBDQ) at week 12. Secondary outcomes included IBDQ subscales; generic HrQoL; disease activity and microbiome. Both groups showed improvement in HrQoL from baseline to post-treatment at week 12. The IBDQ sum score showed no significant group difference (p = 0.251). If patients attended more than 50% of the training sessions, a significant group effect (p = 0.034) was evident in favor of LSM. In addition, the SF-36 mental component summary (p = 0.002) was significantly different between the groups in favor of LSM. Disease activity microbiome and adverse events did not differ. Both a single workshop and a 10-week comprehensive lifestyle-modification program can improve HrQoL in patients with ulcerative colitis in remission with no apparent effects on clinical disease activity. A treatment difference was observed when examining a subsample of patients who attended ≥ 50% of sessions.
Details
- Title
- Comprehensive Lifestyle-Modification in Patients with Ulcerative Colitis–A Randomized Controlled Trial
- Creators
- Jost Langhorst - University of Duisburg-EssenMargarita Schöls - University of Duisburg-EssenZehra Cinar - University of Duisburg-EssenRonja Eilert - University of Duisburg-EssenKerstin Kofink - University of Duisburg-EssenAnna Paul - University of Duisburg-EssenChristina Zempel - University of Duisburg-EssenSigrid Elsenbruch - Ruhr University BochumRomy Lauche - Southern Cross UniversityMohamed Ahmed - Technical University of MunichDirk Haller - Technical University of MunichHolger Cramer - University of Duisburg-EssenGustav Dobos - University of Duisburg-EssenAnna K Koch - University of Duisburg-Essen
- Publication Details
- Journal of Clinical Medicine, Vol.9(10), 3087
- Publisher
- MDPI
- Identifiers
- 991012886299402368
- Copyright
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Academic Unit
- National Centre for Naturopathic Medicine; Faculty of Health
- Language
- English
- Resource Type
- Journal article