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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Cognitive and academic outcomes in children with chronic kidney disease
Pediatric nephrology (Berlin, West), Vol.37, pp.2715-2724
11/2022
PMID: 35243536
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Abstract
Background
Few data exist on the cognitive and academic functioning of children with chronic kidney disease (CKD) over the trajectory of their illness. We aimed to determine the association between CKD stages and cognitive and academic performance in children over time.
Methods
We included 53 participants (aged 6–18 years) with CKD stages 1–5 (n = 37), on dialysis (n = 3), or with functioning kidney transplant (n = 22) from three units in Australia from 2015 to 2019. Participants undertook a series of psychometric tests and were invited for repeated assessments annually. We used linear regression and linear mixed models to investigate the effect of CKD stage, adjusted for socioeconomic status.
Results
At baseline, full-scale intelligence quotient (FSIQ) (95%CI) of children on kidney replacement therapy (KRT) was in the low average range (87: 78, 96) and average (101: 95, 108) for children with CKD 1–5. Mean (95%CI) FSIQ, word reading, numerical operations, and spelling scores for children on KRT were 14.3 (− 25.3, − 3.3), 11 (− 18.5, − 3.6), 8.5 (− 17.6, 0.76), and 10 (− 18.6, − 1.3) points lower than children with CKD Stages 1–5. Spelling and numerical operations scores declined by 0.7 (− 1.4, − 0.1) and 1.0 (− 2.0, 0.2) units per year increase in age, regardless of CKD stage.
Conclusions
Children treated with KRT have low average cognitive abilities and lower academic performance for numeracy and literacy compared to both children with CKD 1–5 and to the general population. However, the rate of decline in academic performance over time is similar for children across the full spectrum of CKD.
Details
- Title
- Cognitive and academic outcomes in children with chronic kidney disease
- Creators
- Siah Kim - Children's Hospital at WestmeadAnita Van Zwieten - Children's Hospital at WestmeadJennifer Lorenzo - Children's Hospital at WestmeadRabia Khalid - Children's Hospital at WestmeadSuncica Lah - The University of SydneyKerry Chen - Children's Hospital at WestmeadMadeleine Didsbury - Children's Hospital at WestmeadAnna Francis - Children's Health Queensland Hospital and Health ServiceSteven Mctaggart - Children's Health Queensland Hospital and Health ServiceAmanda Walker - Royal Children's HospitalFiona E. Mackie - Sydney Children's HospitalChanel Prestidge - Starship Children's HealthArmando Teixeira-Pinto - Children's Hospital at WestmeadAllison Tong - The University of SydneyKatrina Blazek - Children's Hospital at WestmeadBelinda Barton - Children's Hospital at WestmeadJonathan C. Craig - Flinders UniversityGermaine Wong - Children's Hospital at Westmead
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.37, pp.2715-2724
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- Open Access funding enabled and organized by CAUL and its Member Institutions. The KCAD study was supported by the National Health and Medical Research BEAT-CKD program grant and the Ludwig Engel Research Fellowship. GW is supported by a NHMRC career development fellowship (APP 1147657) and the Investigator Grant (APP1195414).
- Identifiers
- 991013093610802368
- Copyright
- © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, (http://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- Faculty of Health
- Language
- English
- Resource Type
- Journal article