Journal article
Clomethiazole for insomnia in older adults: A systematic review and meta-analysis
Pharmacopsychiatry, Vol.55(6), 313
2022
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Abstract
Introduction The objective of this systematic review was to estimate the efficacy and safety of clomethiazole (also called chlormethiazole) in older adults experiencing insomnia (sleep disorder).
Methods A literature search was conducted where electronic databases were searched through December 2021. Manuscripts from Medline (through PubMed), Scopus, the Cochrane Library, PsycINFO, Ovid, ZB MED and PMC were reviewed and analyzed. Randomized controlled trials (RCTs) were eligible if they assessed the effects of clomethiazole on sleep duration, onset of sleep, quality of sleep, adverse events or drop-out rates compared to placebo and other drugs.
Results Eight RCTs with 424 patients were included. Clomethiazole significantly increased the duration of sleep when compared to placebo (SMD=0.61; 95% CI=0.11 to 1.11) while no significant difference was seen compared to other drugs (SMD=–0.07; 95%CI=–0.52 to 0.39). More patients receiving clomethiazole had adequate quality of sleep (OR=1.44; 95% CI=1.04 to 1.98; P=0.03) and also drop-out rates were significantly lower under clomethiazole treatment when compared to other drugs (OR=0.51; 95% CI=0.26 to 0.99; P=0.05).
Conclusion Our results demonstrate superior effects of clomethiazole on the duration of sleep and the quality of sleep in older adults with insomnia in combination with less drop-outs and hang-over effects in comparison to placebo and/or other drugs. Clomethiazole should be taken into account as alternative treatment in in older adults with severe insomnia.
Details
- Title
- Clomethiazole for insomnia in older adults: A systematic review and meta-analysis
- Creators
- Marwaa JuburiHolger CramerMartin Schäfer
- Publication Details
- Pharmacopsychiatry, Vol.55(6), 313
- Publisher
- Georg Thieme Verlag
- Identifiers
- 991013154192602368
- Copyright
- © 2022. Thieme. All rights reserved.
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article