Journal article
Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis
International journal of cardiology, Vol.259, pp.198-204
15/05/2018
PMCID: PMC5875712
PMID: 29579601
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Source: InCites
Abstract
Biomarkers to predict the presence and severity of subclinical cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD) are lacking.
3876 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), without known chronic liver disease underwent baseline non-contrast cardiac CT, with NAFLD defined by validated liver:spleen ratio (L:S) < 1.0, and subclinical CVD defined by coronary artery calcium (CAC) score > 0. Randomly-selected subgroups underwent detailed inflammatory marker testing, including LpPLA2 mass (N = 2951), activity (N = 3020), high-sensitivity C-reactive protein (hsCRP; N = 3849), and interleukin-6 (IL-6; N = 3764). Among those with NAFLD, we estimated the prevalence of CAC > 0 and CAC > 100 for each SD biomarker increase, using multivariable log-binomial regression models adjusted for cardiometabolic risk factors.
Details
- Title
- Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis
- Creators
- Tracey G Simon - Harvard UniversityMaria Esther Perez Trejo - University of WashingtonRobyn McClelland - University of WashingtonRyan Bradley - University of California, San DiegoMichael J Blaha - Johns Hopkins UniversityIrfan Zeb - St. Luke's-Roosevelt Hospital CenterKathleen E Corey - Harvard UniversityMatthew J Budoff - The Lundquist InstituteRaymond T Chung - Harvard University
- Publication Details
- International journal of cardiology, Vol.259, pp.198-204
- Publisher
- Elsevier B.V
- Identifiers
- 991013035746002368
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article