Journal article
Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth. (Myoporaceae)
Phytochemistry, Vol.72(4/5), pp.400-408
2011
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Abstract
<p><p id="x-x-x-x-sp005">A detailed investigation of the wood, leaf, branch and root oil of <em>Eremophila mitchellii</em> (Benth.) was carried out by a combination of GC–FID, GC–MS and NMR. The wood oil was composed predominantly of eremophilanes, a rare class of biologically active, bicyclic sesquiterpenoids. The root oil was also found to contain the eremophilanes together with the zizaene sesquiterpene, sesquithuriferone. 9-Hydroxy-1,7(11),9-eremophilatrien-8-one and the known 1(10),11-eremophiladien-9-one (eremophilone), 9-hydroxy-7(11),9-eremophiladien-8-one (2-hydroxyeremophilone), 8-hydroxy-11-eremophilen-9-one (santalcamphor), 8-hydroxy-10,11-eremophiladien-9-one, sesquithuriferone and 8-hydroxy-1,11-eremophiladien-9-one were purified and elucidated by NMR. Three approaches to the purification of the major eremophilanes from the wood oil are described. (+) Spathulenol, <em>α</em>-pinene, globulol, viridiflorene were the major constituents of the leaf oil. All of the essential oils and the eremophilanes exhibited cytotoxicity against <strong>P388D</strong><sub>1</sub> mouse lymphoblast cells <em>in-vitro</em>.</p>
Details
- Title
- Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth. (Myoporaceae)
- Creators
- Karren D Beattie - Southern Cross UniversityPeter G Waterman - Southern Cross UniversityPaul I Forster - Brisbane Botanic GardensDion R Thompson - Southern Cross UniversityDavid N Leach - Southern Cross University
- Publication Details
- Phytochemistry, Vol.72(4/5), pp.400-408
- Identifiers
- 2121; 991012822126802368
- Academic Unit
- School of Health and Human Sciences; Southern Cross Plant Science
- Resource Type
- Journal article