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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats
Marine Drugs, Vol.18(2), pp.1-26
31/01/2020
PMCID: PMC7073600
PMID: 32023936
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Abstract
Carrageenans are thickening and gelling agents that may provide health benefits. Iota (ι)-carrageenan, a linear sulfated polysaccharide, is produced by the red seaweed, Sarconema filiforme. This study investigated the potential of this seaweed as a functional food for the reversal of metabolic syndrome and possible mechanisms. Male Wistar rats were divided into four groups in a 16-week protocol: corn starch diet-fed rats (C); C rats supplemented with 5% S. filiforme for the last 8 weeks (CSF); high-carbohydrate, high-fat diet-fed rats (H); and H rats supplemented with 5% S. filiforme for the last 8 weeks (HSF). S. filiforme was produced in tank-based aquaculture yielding 27 g dry weight/day/m2 of culture area. H rats developed obesity, hypertension, dyslipidaemia, glucose intolerance, fatty liver and increased left ventricular collagen deposition. S. filiforme supplementation decreased body weight, abdominal and liver fat, systolic blood pressure, plasma total cholesterol concentrations, and plasma activities of alanine transaminase and aspartate transaminase. S. filiforme supplementation modulated gut microbiota without changing the Firmicutes to Bacteroidetes ratio. S. filiforme improved symptoms of high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Possible mechanisms include a reduced infiltration of inflammatory cells into organs as well as prebiotic actions in the gastrointestinal tract.
Details
- Title
- Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats
- Creators
- Ryan du Preez - School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, AustraliaNicholas Paul - School of Science and Engineering, University of the Sunshine Coast, Maroochydore, QLD 4558, AustraliaPeter Mouatt - Southern Cross UniversityMarwan E Majzoub - School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaTorsten Thomas - School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSunil K Panchal - Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, AustraliaLindsay Brown - School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia
- Publication Details
- Marine Drugs, Vol.18(2), pp.1-26
- Publisher
- MDPI AG; Switzerland
- Grant note
- SRF09 / University of Southern Queensland This research was funded by University of Southern Queensland Research and Innovation Division.
- Identifiers
- 991012925428302368
- Copyright
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- Faculty of Science and Engineering; School of Environment, Science and Engineering; Science; Southern Cross Plant Science
- Language
- English
- Resource Type
- Journal article