Journal article
Cardioprotective Diet to Prevent Anthracycline-Induced Cardiotoxicity in Patients with Breast Cancer: A Randomized Open-Label Controlled Trial
Journal of integrative and complementary medicine, Vol.30(10), pp.995-1001
01/10/2024
PMID: 38757731
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Source: InCites
Abstract
Objectives: Several studies have indicated that dietary interventions may offer protection against the development of cardiac damage in the case of anthracycline-induced cardiomyopathy (AIC). The goal of this study was to assess whether an evidence-based cardioprotective diet can be effective in preventing AIC in patients with breast cancer.
Design: Randomized, open-label, controlled trial. The study period was set for 18 weeks, and the data were analyzed by generalized estimating equation modeling and one-way repeated measures analysis of variance.
Setting/Location: Shahid Rajaie Hospital affiliated (Tehran, Iran).
Subjects: Fifty anthracycline-treated patients with breast cancer.
Interventions: Patients were randomized to receive either a 2-hour training in evidence-based cardio-protective diet or Carvedilol 6.25 mg bid.
Outcome Measures: The primary outcome was the number of patients with abnormal left ventricular ejection fraction (LVEF) after 18 weeks.
Results: At week 18, 12 (48%) out of 25 participants in the cardioprotective diet group had abnormal LVEF in comparison with 21 (84%) out of 25 in the carvedilol group (p = 0.007). Also, 2 (8%) out of 25 in the cardioprotective diet group compared with 7 (28%) out of 25 participants in the carvedilol group had abnormal global longitudinal strain (p = 0.066). The diet group showed significant improvements in the quality-of-life dimensions named “health change” and “general health” compared with the carvedilol group using the Short Form-36 Health Survey questionnaire.
Conclusions: This study suggests that an evidence-based cardioprotective diet can contribute to the prevention of AIC. Although current treatments for AIC can be effective, further research is mandatory for more options.
Details
- Title
- Cardioprotective Diet to Prevent Anthracycline-Induced Cardiotoxicity in Patients with Breast Cancer: A Randomized Open-Label Controlled Trial
- Creators
- Azin Alizadehasl - Iran University of Medical SciencesMona Malekzadeh Moghani - Shahid Beheshti University of Medical SciencesHamidreza Mirzaei - Shahid Beheshti University of Medical SciencesMasoumeh Keshvari - Shahid Beheshti University of Medical SciencesFatemeh Fadaei - Shahid Beheshti University of Medical SciencesHolger Cramer - University Hospital Tübingen (Tübingen, Germany)Mehdi Pasalar - Shiraz University of Medical SciencesGhazaleh Heydarirad - Shahid Beheshti University of Medical Sciences
- Publication Details
- Journal of integrative and complementary medicine, Vol.30(10), pp.995-1001
- Publisher
- Mary Ann Liebert, Inc. Publishers
- Identifiers
- 991013190413402368
- Copyright
- Copyright 2024, Mary Ann Liebert, Inc., publishers.
- Academic Unit
- National Centre for Naturopathic Medicine
- Language
- English
- Resource Type
- Journal article