Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index

Antonio Cuesta-Vargas; Jena Buchan; Bella Pajares; Emilio Alba; Cristina Roldan-Jiménez

doi:10.1371/journal.pone.0215662

Back

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index

Journal article

Open access

Peer reviewed

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index

Antonio Cuesta-Vargas, Jena Buchan, Bella Pajares, Emilio Alba and Cristina Roldan-Jiménez

PloS one, Vol.14(4), e0215662

22/04/2019

DOI: https://doi.org/10.1371/journal.pone.0215662

PMCID: PMC6476532

PMID: 31009501

Files and links (2)

pdf

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes442.43 kBDownload View

Published (Version of record)CC BY V4.0, Open Access

url

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomesView

Published (Version of record)CC BY V4.0, Open

Metrics

1 File views/ downloads

6 Record Views

13 Times Cited - Web of Science

See more details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Abstract

Cancer-related fatigue (CRF)

Breast Cancer

Although breast cancer mortality is decreasing, morbidity following treatment remains a significant issue, as patients face symptoms such as cancer-related fatigue (CRF). The aim of the present study is to develop a classification system that monitors fatigue via integration of an objective clinical assessment with patient self-report. Forty-three women participated in this research. Participants were post-treatment breast cancer survivors who had been surgically treated for their primary tumour with no evidence of neoplastic disease at the time of recruitment. Self-perceived fatigue was assessed with the Spanish version of the Piper Fatigue Scale-Revised (R-PFS). Objective fatigue was assessed by the 30 second Sit-to-Stand (30-STS) test. Confirmatory factor analysis was done with Maximum Likelihood Extraction (MLE). Internal consistency was obtained by Cronbach's α coefficients. Bivariate correlation showed that 30-STS performance was negatively-inversely associated with R-PFS. The MANOVA model explained 54.3% of 30-STS performance variance. Using normalized scores from the MLE, a classification system was developed based on the quartiles. This study integrated objective and subjective measures of fatigue to better allow classification of patient CRF experience. Results allowed development of a classification index to classify CRF severity in breast cancer survivors using the relationship between 30-STS and R-PFS scores. Future research must consider the patient-perceived and clinically measurable components of CRF to better understand this multidimensional issue.

Details

Title: Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index
Creators: Antonio Cuesta-Vargas - Universidad de Málaga
Jena Buchan - Griffith University
Bella Pajares - Institute of Biomedical Research in Málaga
Emilio Alba - Universidad de Málaga
Cristina Roldan-Jiménez - Universidad de Málaga
Publication Details: PloS one, Vol.14(4), e0215662
Publisher: Public Library of Science
Grant note: This research project was partially funded by Contract Nº PS16060 in IBIMA between Novartis- IBIMA (Traslation Research in Cancer B-01 & Clinimetric F-14). This consisted on a payment for author CRJ as physical therapist in the assessment. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.
Identifiers: 991013093609602368
Copyright: © 2019 Cuesta-Vargas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index

Files and links (2)

Metrics

UN Sustainable Development Goals (SDGs)

Abstract

Details

Southern Cross University Social media