Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy

Belinda Pan; Noel J. Aherne; Thomas P. Shakespeare; Mathis Grossmann; Peter K.K. Wong

doi:10.5603/RPOR.a2022.0069

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Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy

Journal article

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Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy

Belinda Pan, Noel J. Aherne, Thomas P. Shakespeare, Mathis Grossmann and Peter K.K. Wong

Reports of practical oncology and radiotherapy, Vol.27(4), pp.677-683

19/09/2022

DOI: https://doi.org/10.5603/RPOR.a2022.0069

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Abstract

androgen deprivation

bone density

DXA

osteoporosis

prostate cancer

Research Paper

Background: Androgen deprivation therapy (ADT) is a key component of therapy for patients with high-risk prostate carcinoma, but it may be deleterious for bone health. We sought to determine the frequency of dual energy X-ray absorptiometry (DXA) scanning in patients commencing adjuvant ADT for treatment of high-risk prostate cancer at a large integrated regional cancer centre. Material and methods: The electronic medical records (EMR) of all patients with high-risk prostate carcinoma commenced on adjuvant ADT between January 1, 2016 and December 31, 2017 at the Mid-North Coast Cancer Institute, Coffs Harbour, Australia were reviewed. Patients commenced on neoadjuvant ADT and long-term suppressive ADT for metastatic disease were excluded. The following data were obtained: socio-demographic information, prostate cancer data, ADT details and DXA results. Results: 188 men (mean age ± SD, 75.4 ± 7 years) were commenced on adjuvant ADT for a total duration (mean ± SD) of 23.4 ± 7 months. Most (n = 155/188, 82%) were commenced on leuprorelin acetate. While only 26/188 (14%) had a DXA scan performed prior to ADT, another 133 (71%) had a DXA scan at a median of 20 days (interquartile range 7–98), later. Of the 159 men with DXA readings, 76 (48%) were osteopaenic and 38 (24%) were osteoporotic by DXA criteria. Conclusion: A high level (85%) of DXA scanning in men commencing ADT for prostate cancer can be achieved at a regional centre. The high prevalence (72%) of low bone mass in our unselected cohort underscores the importance of routine DXA scanning to guide bone health management during ADT.

Details

Title: Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy
Creators: Belinda Pan - Department of Medicine, Coffs Harbour Health Campus, New South Wales, Australia.
Noel J. Aherne - Southern Cross University
Thomas P. Shakespeare - University of New South Wales
Mathis Grossmann - University of Melbourne
Peter K.K. Wong - UNSW Sydney
Publication Details: Reports of practical oncology and radiotherapy, Vol.27(4), pp.677-683
Publisher: Via Medica
Identifiers: 991013062312402368
Copyright: © 2022 Greater Poland Cancer Centre. Published by Via Medica. This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
Academic Unit: Coffs Harbour Campus Administration
Language: English
Resource Type: Journal article

Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy

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