Journal article
Bioactivity and chemical characterisation of Lophostemon suaveolens – an endemic Australian Aboriginal traditional medicinal plant
Natural Product Research, Vol.30(6), pp.693-696
2016
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Source: InCites
Abstract
<p><em>Lophostemon suaveolens</em> is a relatively unexplored endemic medicinal plant of Australia. Extracts of fresh leaves of <em>L. suaveolens</em> obtained from sequential extraction with <em>n</em>-hexane and dichloromethane exhibited antibacterial activity in the disc diffusion and MTT microdilution assays against <em>Streptococcus pyogenes</em> and methicillin sensitive and resistant strains of <em>Staphylococcus aureus</em> (minimum bactericidal concentration < 63 μg/mL). The dichloromethane extract and chromatographic fractions therein inhibited nitric oxide in RAW264.7 murine macrophages (IC<sub>50</sub> 3.7–11.6 μg/mL) and also PGE<sub>2</sub> in 3T3 murine fibroblasts (IC<sub>50</sub> 2.8–19.7 μg/mL). The crude <em>n</em>-hexane, dichloromethane and water extracts of the leaves and chromatographic fractions from the dichloromethane extract also showed modest antioxidant activity in the ORAC assay. GC–MS analysis of the <em>n</em>-hexane fraction showed the presence of the antibacterial compounds aromadendrene, spathulenol, β-caryophyllene, α-humulene and α-pinene and the anti-inflammatory compounds β-caryophyllene and spathulenol. Fractionation of the dichloromethane extract led to the isolation of eucalyptin and the known anti-inflammatory compound betulinic acid.</p>
Details
- Title
- Bioactivity and chemical characterisation of Lophostemon suaveolens – an endemic Australian Aboriginal traditional medicinal plant
- Creators
- Tarannum Naz - Macquarie UniversityJoanne Packer - Macquarie UniversityPing Yin - Macquarie UniversityJoseph J Brophy - University of New South WalesHans Wohlmuth - Southern Cross UniversityDane E Renshaw - Southern Cross UniversityJoshua Smith - University of New EnglandYaegl Community Elders - Yaegl Local Aboriginal Land Council, Maclean, NSWSubramanyam R Vemulpad - Macquarie UniversityJoanne F Jamie - Macquarie University
- Publication Details
- Natural Product Research, Vol.30(6), pp.693-696
- Identifiers
- 1845; 991012821182302368
- Academic Unit
- Office of Deputy Vice Chancellor, Research; Southern Cross Plant Science
- Resource Type
- Journal article