Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study

Ysabel Jacob; Ryan S. Anderton; Jodie Cochrane Wilkie; Brent Rogalski; Simon M. Laws; Anthony Jones; Tania Spiteri; Nicolas H. Hart

doi:10.3390/sports9020022

Back

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study

Journal article

Open access

Peer reviewed

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study

Ysabel Jacob, Ryan S. Anderton, Jodie Cochrane Wilkie, Brent Rogalski, Simon M. Laws, Anthony Jones, Tania Spiteri and Nicolas H. Hart

Sports (Basel), Vol.9(2), pp.1-12

29/01/2021

DOI: https://doi.org/10.3390/sports9020022

PMID: 33572708

Files and links (2)

pdf

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study289.31 kBDownload View

Published (Version of record)CC BY V4.0, Open Access

url

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary StudyView

Published (Version of record)CC BY V4.0, Open

Metrics

3 File views/ downloads

20 Record Views

2 Times Cited - Web of Science

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Abstract

Life Sciences & Biomedicine

Science & Technology

Sport Sciences

ADRB1

PPARGC1a

genes

sport

performance

Australian Football

endurance

Genetic variants in the angiotensin-converting enzyme (ACE) (rs4343), alpha-actinin-3 (ACTN3) (rs1815739), adrenoceptor-beta-1 (ADRB1) (rs1801253), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) (rs8192678) genes have previously been associated with elite athletic performance. This study assessed the influence of polymorphisms in these candidate genes towards endurance test performance in 46 players from a single Australian Football League (AFL) team. Each player provided saliva buccal swab samples for DNA analysis and genotyping and were required to perform two independent two-kilometre running time-trials, six weeks apart. Linear mixed models were created to account for repeated measures over time and to determine whether player genotypes are associated with overall performance in the two-kilometre time-trial. The results showed that the ADRB1 Arg389Gly CC (p = 0.034) and PPARGC1A Gly482Ser GG (p = 0.031) genotypes were significantly associated with a faster two-kilometre time-trial. This is the first study to link genetic polymorphism to an assessment of endurance performance in Australian Football and provides justification for further exploratory or confirmatory studies.

Details

Title: Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study
Creators: Ysabel Jacob - Edith Cowan University
Ryan S. Anderton - The University of Notre Dame Australia
Jodie Cochrane Wilkie - Edith Cowan University
Brent Rogalski - West Coast Eagles Football Club, Perth 6100, Australia.
Simon M. Laws - Curtin University
Anthony Jones - West Coast Eagles Football Club, Perth 6100, Australia.
Tania Spiteri - Edith Cowan University
Nicolas H. Hart - Edith Cowan University
Publication Details: Sports (Basel), Vol.9(2), pp.1-12
Publisher: Mdpi
Number of pages: 12
Grant note: Cancer Council of Western Australia Research Fellowship; Cancer Council Western Australia Australian Government Research Training Program Scholarship; Australian Government; Department of Industry, Innovation and Science
Identifiers: 991013087510102368
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Academic Unit: Faculty of Health
Language: English
Resource Type: Journal article

Association of Genetic Variances in ADRB1 and PPARGC1a with Two-Kilometre Running Time-Trial Performance in Australian Football League Players: A Preliminary Study

Files and links (2)

Metrics

UN Sustainable Development Goals (SDGs)

Abstract

Details

Southern Cross University Social media