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Assessment of genetic referrals and outcomes for women with triple negative breast cancer in regional cancer centres in Australia
Published (Version of record)CC BY V4.0, Open
Journal article
Assessment of genetic referrals and outcomes for women with triple negative breast cancer in regional cancer centres in Australia
Hereditary cancer in clinical practice, Vol.19(1), 19
2021
PMID: 33637119
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Source: InCites
Abstract
Guidelines for referral to cancer genetics service for women diagnosed with triple negative breast cancer have changed over time. This study was conducted to assess the changing referral patterns and outcomes for women diagnosed with triple negative breast cancer across three regional cancer centres during the years 2014-2018.
Following ethical approval, a retrospective electronic medical record review was performed to identify those women diagnosed with triple negative breast cancer, and whether they were referred to a genetics service and if so, the outcome of that genetics assessment and/or genetic testing.
There were 2441 women with newly diagnosed breast cancer seen at our cancer services during the years 2014-2018, of whom 237 women were diagnosed with triple negative breast cancer. Based on age of diagnosis criteria alone, 13% (31/237) of our cohort fulfilled criteria for genetic testing, with 81% (25/31) being referred to a cancer genetics service. Of this group 68% (21/31) were referred to genetics services within our regions and went on to have genetic testing with 10 pathogenic variants identified; 5x BRCA1, 4x BRCA2 and × 1 ATM:c.7271 T > G.
Referral pathways for women diagnosed with TNBC to cancer genetics services are performing well across our cancer centres. We identified a group of women who did not meet eligibility criteria for referral at their time of diagnosis, but would now be eligible, as guidelines have changed. The use of cross-discipline retrospective data reviews is a useful tool to identify patients who could benefit from being re-contacted over time for an updated cancer genetics assessment.
Details
- Title
- Assessment of genetic referrals and outcomes for women with triple negative breast cancer in regional cancer centres in Australia
- Creators
- Lucie G Hallenstein (Author) - Mid North Coast Cancer Institute, Coffs HarbourCarol Sorensen (Author) - Mid North Coast Cancer Institute, Port MacquarieLorraine Hodgson (Author) - Kingscliff Community HealthShelly Wen (Author) - Mid North Coast Cancer Institute, Coffs HarbourJustin Westhuyzen (Author) - Mid North Coast Cancer Institute, Coffs HarbourCarmen Hansen (Author) - Mid North Coast Cancer Institute, Coffs HarbourAndrew T J Last (Author) - Mid North Coast Cancer Institute, Coffs HarbourJulan V Amalaseelan (Author) - North Coast Cancer Institute, LismoreShehnarz Salindera (Author) - University of New South WalesWilliam Ross (Author) - University of New South WalesAllan D Spigelman (Author) - St Vincent's Hospital, SydneyThomas P Shakespeare (Author) - University of New South WalesNoel J Aherne (Author) - Southern Cross University
- Publication Details
- Hereditary cancer in clinical practice, Vol.19(1), 19
- Publisher
- BioMed Central Ltd.; Poland
- Identifiers
- 991012925489402368
- Academic Unit
- School of Health and Human Sciences; Coffs Harbour Campus Administration; Faculty of Health
- Language
- English
- Resource Type
- Journal article