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Published (Version of record)CC BY V4.0, Open
Journal article
Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance
Progress in biomedical engineering, Vol.7(3), pp.1-18
15/05/2025
PMID: 40328290
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Abstract
Optical coherence elastography (OCE) is a non-invasive imaging technique that measures the biomechanical properties of materials and tissues. This systematic review focuses on the applications of OCE in the anterior segment of the eye, including the cornea, iris, and crystalline lens, and its clinical relevance in diagnosing and managing ocular diseases. A systematic literature review was conducted using the PRISMA framework to identify studies published between 2014 and 2024. The review included studies that reported intrinsic biomechanical properties of anterior segment tissues measured using OCE. Databases searched included Scopus, Pub Med, and IEEE Xplore. Twenty-five studies met the inclusion criteria. The review found that OCE has been used to measure intrinsic biomechanical parameters such as Young’s modulus and shear modulus in ocular tissues. OCE has been utilised to assess corneal stiffness in keratoconus, lens elasticity in presbyopia and cataract formation, and iris biomechanical changes under different lighting conditions. The studies demonstrated that OCE could detect subtle biomechanical changes associated with ocular diseases and measure treatment efficacy, such as collagen crosslinking for keratoconus management. The findings highlight the potential of OCE to enhance clinical diagnostics and patient care by providing detailed insights into the biomechanical properties of ocular tissues. However, variability in measurement techniques, the complexity of the method and reliance on animal models limit the current clinical translation of OCE. Standardised measurement protocols and further development and in vivo validation are needed to overcome these barriers. OCE shows promise as a valuable non-invasive tool for high-resolution assessments of tissue biomechanics, which can subsequently support the diagnosis and management of ocular diseases. Future research should focus on standardising OCE methods and integrating them into clinical practice to fully realise their potential in improving patient outcomes.
Details
- Title
- Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance
- Creators
- Zachery Quince - Queensland University of TechnologyNicola Westerman - University of Southern QueenslandDavid Alonso-Caneiro - University of the Sunshine CoastScott A Read - Queensland University of TechnologyMichael Collins - Queensland University of Technology
- Publication Details
- Progress in biomedical engineering, Vol.7(3), pp.1-18
- Publisher
- IOP Publishing Ltd
- Grant note
- This work was funded by the University of Southern Queensland through a Research Collaboration Grant with Queensland University of Technology.
- Identifiers
- 991013285448602368
- Copyright
- © 2025 The Author(s). Published by IOP Publishing Ltd Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
- Academic Unit
- Centre for Teaching and Learning; Faculty of Science and Engineering
- Language
- English
- Resource Type
- Journal article