Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future

Xiaonan Zhang; Xiaomeng Wang; Min Wu; Reena Ghildyal; Zhenghong Yuan

doi:10.3389/fmicb.2021.715450

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Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future

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Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future

Xiaonan Zhang, Xiaomeng Wang, Min Wu, Reena Ghildyal and Zhenghong Yuan

Frontiers in microbiology, Vol.12, pp.1-10

16/07/2021

DOI: https://doi.org/10.3389/fmicb.2021.715450

PMID: 34335553

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Abstract

Life Sciences & Biomedicine

Microbiology

Science & Technology

animal model

HBV

CccDNA

chronic hepatitis B

humanized mice

Hepatitis B virus (HBV) infection is a global public health problem that plagues approximately 240 million people. Chronic hepatitis B (CHB) often leads to liver inflammation and aberrant repair which results in diseases ranging from liver fibrosis, cirrhosis, to hepatocellular carcinoma. Despite its narrow species tropism, researchers have established various in vivo models for HBV or its related viruses which have provided a wealth of knowledge on viral lifecycle, pathogenesis, and immunity. Here we briefly revisit over five decades of endeavor in animal model development for HBV and summarize their advantages and limitations. We also suggest directions for further improvements that are crucial for elucidation of the viral immune-evasion strategies and for development of novel therapeutics for a functional cure.

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Title: Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future
Creators: Xiaonan Zhang - University of Canberra
Xiaomeng Wang - Fudan University
Min Wu - Fudan University
Reena Ghildyal - University of Canberra
Zhenghong Yuan - Fudan University
Publication Details: Frontiers in microbiology, Vol.12, pp.1-10
Publisher: Frontiers Media Sa
Number of pages: 10
Identifiers: 991013036333502368
Copyright: Copyright © 2021 Zhang, Wang, Wu, Ghildyal and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Academic Unit: National Centre for Naturopathic Medicine
Language: English
Resource Type: Journal article

Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future

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