Files and links (2)
Published (Version of record)CC BY-NC V4.0, Open Access
Published (Version of record)CC BY-NC V4.0, Open
Journal article
An Unusual Case of Lorlatinib-Induced Pneumonitis: A Case Report
Case reports in oncology, Vol.15(1), pp.225-230
01/2022
PMID: 35431862
Metrics
1 File views/ downloads
5 Record Views
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Abstract
The discovery of tyrosine kinase oncogenic driver mutations, including anaplastic lymphoma kinase (ALK), has changed the face of non-small cell lung cancer (NSCLC) treatment. Whilst the development of tyrosine kinase inhibitors has improved survival, with their increasing use, it is important to be aware of the risks of rare yet serious adverse events, such as drug-induced pulmonary toxicity. Whilst little is known in regard to drug-induced pneumonitis in the setting of ALK inhibitors, such reactions carry a high morbidity and mortality rate, impacting greatly upon options for further treatment and management. We describe the case of a 73-year-old female with metastatic ALK-positive NSCLC who developed subacute dyspnoea 3 weeks after commencing lorlatinib. She was diagnosed with drug-induced pneumonitis, from which she recovered clinically following the cessation of her targeted therapy. Pneumonitis related to lorlatinib is a rare pulmonary toxicity, and early recognition and intervention is critical to reduce the associated risks of respiratory failure and death.
Details
- Title
- An Unusual Case of Lorlatinib-Induced Pneumonitis: A Case Report
- Creators
- P. K. Harrison - Wagga Wagga Base HospitalH. E. Boland - Wagga Wagga Base HospitalNoel J Aherne - Wagga Wagga Base HospitalD. J. Palmieri - Wagga Wagga Base Hospital
- Publication Details
- Case reports in oncology, Vol.15(1), pp.225-230
- Publisher
- S. Karger AG
- Identifiers
- 991013097818702368
- Copyright
- © 2022 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
- Academic Unit
- Coffs Harbour Campus Administration
- Language
- English
- Resource Type
- Journal article