A review of the role of endo/sarcoplasmic reticulum-mitochondria ca2+ transport in diseases and skeletal muscle function

S S Zhang; S Zhou; Z J Crowley-McHattan; R Y Wang; J P Li

doi:10.3390/ijerph18083874

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A review of the role of endo/sarcoplasmic reticulum-mitochondria ca2+ transport in diseases and skeletal muscle function

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A review of the role of endo/sarcoplasmic reticulum-mitochondria ca2+ transport in diseases and skeletal muscle function

S S Zhang, S Zhou, Z J Crowley-McHattan, R Y Wang and J P Li

International Journal of Environmental Research and Public Health, Vol.18(8), p.3874

2021

DOI: https://doi.org/10.3390/ijerph18083874

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Abstract

mitochondrial calcium overload

Review

endo

sarcoplasmic reticulum-mitochondria Ca2+ transport

skeletal muscle function

mitochondria-associated membrane

Expanding Knowledge in the Medical and Health Sciences

The physical contact site between a mitochondrion and endoplasmic reticulum (ER), named the mitochondria-associated membrane (MAM), has emerged as a fundamental platform for regulating the functions of the two organelles and several cellular processes. This includes Ca 2+ transport from the ER to mitochondria, mitochondrial dynamics, autophagy, apoptosis signalling, ER stress signalling, redox reaction, and membrane structure maintenance. Consequently, the MAM is suggested to be involved in, and as a possible therapeutic target for, some common diseases and impairment in skeletal muscle function, such as insulin resistance and diabetes, obesity, neurodegenerative diseases, Duchenne muscular dystrophy, age-related muscle atrophy, and exercise-induced muscle damage. In the past decade, evidence suggests that alterations in Ca 2+ transport from the ER to mitochondria, mediated by the macromolecular complex formed by IP 3 R, Grp75, and VDAC1, may be a universal mechanism for how ER-mitochondria cross-talk is involved in different physiological/pathological conditions mentioned above. A better understanding of the ER (or sarcoplasmic reticulum in muscle)-mitochondria Ca 2+ transport system may provide a new perspective for exploring the mechanism of how the MAM is involved in the pathology of diseases and skeletal muscle dysfunction. This review provides a summary of recent research findings in this area.

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Title: A review of the role of endo/sarcoplasmic reticulum-mitochondria ca2+ transport in diseases and skeletal muscle function
Creators: S S Zhang (Author) - Beijing Sport University
S Zhou (Author) - Southern Cross University
Z J Crowley-McHattan (Author) - Southern Cross University
R Y Wang (Author) - Beijing Sport University
J P Li (Author) - Beijing Sport University
Publication Details: International Journal of Environmental Research and Public Health, Vol.18(8), p.3874
Publisher: MDPI AG
Identifiers: 991012925900502368
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Academic Unit: Human Sciences; Faculty of Health
Language: English
Resource Type: Journal article

A review of the role of endo/sarcoplasmic reticulum-mitochondria ca2+ transport in diseases and skeletal muscle function

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