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Published (Version of record)CC BY V4.0, Open Access
Published (Version of record)CC BY V4.0, Open
Journal article
A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
Nutrients, Vol.14(3559), pp.1-14
29/08/2022
PMCID: PMC9460714
PMID: 36079816
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Abstract
Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 ± 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups—only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.
Details
- Title
- A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
- Creators
- Michael Jeitler - Humboldt-Universität zu BerlinRomy Lauche - Southern Cross UniversityChristoph Hohmann - Immanuel KrankenhausKyung-Eun Choi - University of CologneNadia Schneider - University of Duisburg-EssenNico Steckhan - Humboldt-Universität zu BerlinFlorian Rathjens - University of Duisburg-EssenDennis Anheyer - University of Duisburg-EssenAnna Paul - University of Duisburg-EssenChristel von Scheidt - Immanuel KrankenhausThomas Ostermann - Witten/Herdecke UniversityElisabeth Schneider - Humboldt-Universität zu BerlinDaniela Koppold-Liebscher - Humboldt-Universität zu BerlinChristian S. Kessler - Charité - Universitätsmedizin BerlinGustav Dobos - University of Duisburg-EssenAndreas Michalsen - Charité - Universitätsmedizin BerlinHolger Cramer - Southern Cross University
- Publication Details
- Nutrients, Vol.14(3559), pp.1-14
- Publisher
- MDPI AG
- Grant note
- This work was supported by Corona-Foundation, Germany (funding number: S199/10056/2012). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. We acknowledge financial support from the Open Access Publication Fund of Charité-Universitätsmedizin Berlin and the German Research Foundation (DFG).
- Identifiers
- 991013051613702368
- Copyright
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Academic Unit
- National Centre for Naturopathic Medicine; Faculty of Health
- Language
- English
- Resource Type
- Journal article