Investigating the role of intestinal microflora in the aetiology, symptom scores and life quality of people with coeliac disease

Coeliac disease (CD) is a disorder resulting from the interaction between diet, genome and immunity. CD can present at any age, affecting intestinal and extra-intestinal organ systems. Treatment of CD is a life-long adherence to a gluten-free diet. The aim of this thesis was to investigate the role of intestinal microflora in the aetiology and ongoing clinical management of patients with CD. A survey explored childhood health factors that affect the development of the intestinal microflora. A randomised control trial investigated the composition of the gastrointestinal microflora in individuals with CD followed by a probiotic intervention and reassessment.