Review
Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review
Critical reviews in environmental science and technology, Vol.51(7), pp.704-750
03/04/2021
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Source: InCites
Abstract
This review highlights arsenic (As) and selenium (Se) sources in the environment, their uptake in the soil-plant system, interactions between these metals and the associated toxicity in major biological compartments, which may assist in addressing the hazardous impacts associated with As and Se contamination. The interaction between As and Se is a critical factor for a detailed systematic understanding of the transportation, environmental fate, and associated toxicological effects of these metalloids in plants, animals, and humans. Arsenic and Se induce cytotoxicity and genotoxicity through the generation of reactive oxygen species (ROS). Compared to arsenite (AsIII), methylated arsenicals, including methylarsonous acid (MAsIII) and dimethylarsinous acids (DMAsIII), exhibit more cytotoxic and genotoxic potential to inhibit more potent enzymes and activate the protein AP˗1, which is a critical marker of genetic stability. Methylated AsIII and its associated metabolites are well-known potential carcinogens that induce toxicity by blocking Se metabolism pathway. The imbalance of Se compounds can lead to the generation of ROS, which can inhibit or decrease genomic stability. The As and Se nexus also affect cellular signaling through activation of transcription factors such as NFκB and AP-1.
Details
- Title
- Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review
- Creators
- Waqar Ali - University of Chinese Academy of SciencesHua Zhang - Institute of GeochemistryMuhammad Junaid - Peking UniversityKang Mao - Institute of GeochemistryNan Xu - Peking UniversityChuanyu Chang - University of Chinese Academy of SciencesAtta Rasool - COMSATS University IslamabadMuhammad Wajahat Aslam - University of Chinese Academy of SciencesJamshed Ali - University of Chinese Academy of SciencesZhugen Yang - Cranfield University
- Publication Details
- Critical reviews in environmental science and technology, Vol.51(7), pp.704-750
- Publisher
- Taylor & Francis
- Grant note
- U1612442 / National Science Foundation of China-Project of Karst Science Research Center YFC1803600; 2017YFD0800302 / National Key Research and Development Program of China 2019)5618/2019(2963 / Science and Technology program of Guizhou Province
- Identifiers
- 991013092673902368
- Copyright
- (c) 2020 Taylor & Francis Group, LLC
- Academic Unit
- Faculty of Science and Engineering
- Language
- English
- Resource Type
- Review